Conference of RNA, Exosome and Nanomedicine
5th International Conference on Biomotors, Virus Assembly, and RNA Nanobiotechnology
Hosted by: International Society of RNA Nanotechnology & Nanomedicine (ISRNN) , The International Association of Biomedical Sciences (IABS)
Co-sponsered by: Center for RNA Nanobiotechnology and Nanomedicine AND Center for RNA Biology , The Ohio State University
MENU
Chair and Co-chair
Organizers and Scientific Program Committees
Speakers and Session Chairs
Abstract Submission
Poster Submission
Conference Hotel
Sponsorship Program
Contact:
conference@ia-bs.org


| Registration Fees | |
| PI / Scientist / Clinician | $ 590 |
| Postdoc / PhD / Graduate /Undergraduate | $ 390 |
| High schoolers | $ 200 |
| Oline | $ 230 |
We are pleased to announce the Conference of RNA, Exosome and Nanomedicine. This is the 5th installment of the biennial International Conference on Biomotors, Virus Assembly, and RNA Nanobiotechnology series since 2017. Due to the RNA field arriving as the third milestone in pharmaceutical drug development, we extended the previous conference series to focus on RNA for this conference. Since exosomes contain many RNAs inside and RNA can display on the surface of exosomes for the purpose of RNA delivery, exosome is another focus of this conference. This interdisciplinary conference includes leading scientists and engineers working in the diverse fields of chemistry, biochemistry, biophysics, structural biology, microbiology, cell biology, materials, and nanotechnology to participate. We invite you to join us in this exciting conference featuring interdisciplinary talks from many fields of groundbreaking research.
To ensure the promotion of high quality and effective academic communication, the conference will be limited to 300 attendees and 50 invited speakers that will be selected from the current more than 200 candidates recommended by members of the Scientific Committee. Registration will be accepted first come first-served basis till the 300 slots are filled. All members of the ISRNN (International Society of RNA Nanotechnology and Nanomedicine https://www.myisrnn.org/ ) and IABS (International Association of Biomedical Sciences https://ia-bs.org/ ) will provide a $100-discount on registration fee and a waiver for the publication fee on journal RNA NanoMed for the year of 2025 (see journal web site https://rnananomed.org/ and its papers indexed by Pubmed https://pubmed.ncbi.nlm.nih.gov/?term=%22RNA+NanoMEd%22%5BJournal%5D&sort ).
Conference Chair

Peixuan Guo
Fellow of National Academy of Inventors,
Editor in Chief of RNA NanoMed,
Sylvan Frank Endowed Chair,
College of Pharmacy,
College of Medicine,
Director, Center for
RNA Nanobiotech & Nanomed,
President, Intl. Society of
RNA Nanotech & Nanomed (ISRNN),
The Ohio State University
Co-chair

Professor;
Dept. of Chemistry;
University of North Carolina
– Charlotte, USA

Professor;
Dept. of Chemistry
and Biochemistry;
The Ohio State University,
Columbus, USA

T.C. Jenkins Professor;
Dept. of Biophysics;
Johns Hopkins University,
Baltimore, USA

Professeur(e) Emérite
Institut de biologie;
Université de Strasbourg,
Strasbourg, France
Organizers and Scientific Program Committees:

Sarah Woodson
Scientific Committee Chair;
Professor; Johns Hopkins University, USA

Kirill Afonin
Scientific Committee Member;
Professor; University of North Carolina – Charlotte, USA

Peixuan Guo
Scientific Committee Member;
Professor & Director of Center for RNA Nanobiotechnology and Nanomedicine;
The Ohio State University, USA

Daniel Binzel
Scientific Committee Member;
Research Assistant Professor;
The Ohio State University, USA

Karin Musier-Forsyth
Scientific Committee Member;
Professor; The Ohio State University, USA

Aijun Wang
Scientific Committee Member;
Professor; University of California, Davis, USA

Eric Westhof
Scientific Committee Member;
Professeur(e) Emérite;
Université de Strasbourg, France
Speakers and Session Chairs (listed in first name alphabetical order)








Abstract Submission
Please download the abstract template for your abstract preparation. ( Click Here )
Poster Submission
Poster size: 40″ Wx 30″ H. Email your PDF file to conference@ia-bs.org before December 1, 2025. Save your file as “your Name-2025 Poster”.
If you need printing by the conference organizer. A fee of $90 will apply for this service.” ( Click Here )
.
Hotel Information
DoubleTree by Hilton Los Angeles – Rosemead
Address: 888 Montebello Blvd, Rosemead, CA 91770
Phone: +1 323-722-8800
Book Your Room:
www.LosAngelesRosemead.DoubleTree.com
After booking your hotel using the link above, please provide us with your names by emailing conference@ia-bs.org.
We can request the hotel to reimburse the difference so your rate matches the conference discount rate of $155 before tax, which includes free breakfast and free parking.
Airports
Ontario International Airport (ONT)
2500 E. Airport Drive
Ontario, CA 91761, USA
Website: https://www.flyontario.com/
Los Angeles International Airport (LAX)
1 World Way
Los Angeles, CA 90045, USA
Website: https://www.flylax.com/


Acknowledgment of Financial Sponsors:
1. National Institutes of Health, National Center for Advancing Translational Sciences
Scientific Sponsors:
1. The Ohio State University
2. Center for RNA Nanobiotechnology and Nanomedicine, OSU
3. Center for RNA Biology, OSU
4. College of Pharmacy, OSU
5. International Society of RNA Nanotechnology and Nanomedicine
6. International Association of Biomedical Sciences
.
TENTATIVE AGENDA
| Scientific Program December 15 – 17, 2025 |
MONDAY, DECEMBER 15, 2025
| 9:00 AM | Ballroom | ||
| 9:00 – 9:30 AM | Peixuan Guo; The Ohio State University, USA Introduction: The Current Advancement of RNA Nanotechnology, Extracellular Vesicles, and RNA-displaying EVs | ||
| 9:30 AM | |||
| SESSION 1: RNA, Virus Assembly, and Exosomes | Ballroom | ||
| Session Moderator: Peixuan Guo & Thomas Webster | |||
| 9:30 – 10:00 AM | Karin Musier-Forsyth; The Ohio State University, USA How Structure Determines HIV-1 Unspliced RNA Fate: A Tale of Two Gs | ||
| 10:00 – 10:30 AM | Zihe Rao; Tsinghua University, China Cryo-EM Structural Imaging of the Revolving Hexameric DNA Packaging Motor of Human Herpesvirus | ||
| 10:30 – 11:00 AM | Meeting Logistics and Break | ||
| 11:00 – 11:30 AM | Aijun Wang; University of California Davis, USA Engineering Extracellular Vesicles and Lipid Nanoparticles for Targeted Delivery and Therapy | ||
| 11:30 – 12:00 PM | Gene Yeo; University of California San Diego, USA Discovery of Circular RNA Biogenesis Regulators | ||
| 12:00 PM | Break for Lunch | ||
| 1:30 PM | |||
| SESSION 2: RNA Structure, Aggregation, and Nanotechnology | Ballroom | ||
| Session Moderator: Jane Jackman & Julie Feigon | |||
| 1:30 – 2:00 PM | Jeffrey Kieft; New York Structural Biology Center and Columbia University, USA Viral RNA Structures that Manipulate Cellular Machinery | ||
| 2:00 – 2:30 PM | Kirill Afonin; University of North Carolina Charlotte, USA Nucleic Acid Nanoparticles for Biomedical Applications | ||
| 2:30 – 3:00 PM | Sarah Woodson; Johns Hopkins University, USA Mechanisms of RNA Aggregation in Triplet Repeat Expansion Disease | ||
| 3:00 PM | Break | ||
| 3:30 PM | |||
| SESSION 3A: RNA with Unique Functionality: Small Noncoding RNA and Long Noncoding RNA (1) | La Brea Room | ||
| Session Moderator: Yibin Feng & Soma Dhakal | |||
| 3:30 – 3:50 PM | Rajgopal Govindarajan; The Ohio State University, USA Cardioprotective SNPs in SLC28A3 and lncRNA SLC28A3-AS1 Result in Transcriptional Changes and Alternative Splicing to Reduce Doxorubicin Cytotoxicity | ||
| 3:50 – 4:10 PM | Wenqiang Yu; Fudan University, China NamiRNA-Enhancer Network as Novel Target for Developing Small Nuclear Acid Therapy | ||
| 4:10 – 4:30 PM | Tae Jin Lee; University of Texas Health Science Center at Houston, USA Targeting microRNAs for Treating Glioblastoma with Engineered Extracellular Vesicles | ||
| 4:30 – 4:50 PM | Yibin Feng; The University of Hong Kong, Hong Kong Multidisciplinary research and drug discovery in Chinese medicine: coptis and berberine as the case | ||
| SESSION 3B: RNA Processing and Regulation | Ballroom | ||
| Session Moderator: Karin Musier-Forsyth & Gene Yeo | |||
| 3:30 – 3:50 PM | Ambro van Hoof; The Ohio State University, USA tRNA Splicing Endonuclease is a Multifunctional Enzyme with Roles in Maturation and Degradation of Diverse RNA | ||
| 3:50 – 4:10 PM | Kay Choi; Indiana University, USA Lessons from the Structure of the HIV Rev Response Element | ||
| 4:10 – 4:30 PM | Kristin Koutmou; University of Michigan, USA The Molecular Level Consequences of RNA Modifications on Protein Synthesis | ||
| 4:30 – 4:50 PM | Shipra Agrawal; Stony Brook University, USA Alternative RNA Splicing and Polyadenylation in Chronic Kidney Disease | ||
| 4:50 PM | Break | ||
| 5:10 PM | |||
| SESSION 4A: RNA with Unique Functionality: Small Noncoding RNA and Long Noncoding RNA (2) | La Brea Room | ||
| Session Moderator: Kirill Afonin & Elisa Franco | |||
| 5:10 – 5:30 PM | Wen Zhang; Indiana University, USA Mirror-image Nucleic Acids as Next-generation Reagents for Basic Research and Therapeutic Applications | ||
| 5:30 – 5:50 PM | Daniel Binzel; The Ohio State University, USA RNA Nanoparticles Harboring Radioisotopes or Other Imaging Molecules for Spontaneous Tumor Targeting for Early Cancer Diagnosis | ||
| 5:50 – 6:10 PM | Kai Jin; The Ohio State University, USA — Selected Student Talk Illustration of the Variable 1D Sequences and Conserved 2D and 3D Structures of Different ncRNA Nanostructures for Tracking the Evolution and Origin of Organisms | ||
| 6:10 – 6:30 PM | Lalit Sehgal; The Ohio State University, USA MALAT1 Long-Non-Coding RNA Regulates SOX11 Expression in Mantle Cell Lymphoma | ||
| SESSION 4B: Advances in RNA Therapeutics and RNA Delivery Vehicles | Ballroom | ||
| Session Moderator: Aijun Wang & Eunji Chung | |||
| 5:10 – 5:30 PM | Thomas Webster; Brown University, USA Human Nanomedicine: Using the G^C DNA Motif to Grow Tissue, Fight Infection, and Inhibit Inflammation | ||
| 5:30 – 5:50 PM | Minsun Song; City of Hope, USA Transferrin Receptor-Targeted RNA Aptamer Enhances Blood-Brain Barrier Penetration in Brain Metastases from Triple-Negative Breast Cancer | ||
| 5:50 – 6:10 PM | Marina Dobrovolskaia; Nanotechnology Characterization Laboratory, USA Translational Journey of Nanomedicines: General and RNA- Nanotechnology-specific Challenges, Solutions and Perspective from the Nanotechnology Characterization Laboratory Assay Cascade Experiences | ||
| 6:10 – 6:30 PM | Elisa Franco; University of California Los Angeles, USA Programmable Artificial RNA Condensates in Mammalian Cells | ||
| 6:40 PM | Break for Dinner | ||
| 8:00 PM | Social Hour | ||
TUESDAY, DECEMBER 16, 2025
| 9:00 AM | ||
| SESSION 5A: RNA Structure and Function to Build Biological Machines | Ballroom | |
| Session Moderator: Sarah Woodson & Deepak Koirala | ||
| 9:00 – 9:20 AM | Jane Jackman; The Ohio State University, USA Harnessing the Unusual Chemistry and Biology of tRNA Modification Enzymes | |
| 9:20 – 9:40 AM | Lela Lackey; Clemson University, USA Sequence and structural characteristics of conserved splice junctions surrounding neural microexons | |
| 9:40 – 10:00 AM | Yin Chen; University of Arizona, USA MARCKS-driven nano-defenders (MDND) as a prototype for novel anti-infectious therapy | |
| 10:00 – 10:20 AM | Yun-xing Wang; National Cancer Institute, USA RNA Conformational Space Beyond Static Structure | |
| SESSION 5B: Cellular Function Regulated by RNA | La Brea Room | |
| Session Moderator: Wayne Miles & Alex Johnson-Buck | ||
| 9:00 – 9:20 AM | Jaimie Stewart; University of California Los Angeles, USA Building and Tuning Synthetic RNA Condensates: Experimental Design Principles and Computational Insights | |
| 9:20 – 9:40 AM | Deepak Koirala; University of Maryland Baltimore, USA RNA Structure-Based Strategies of Cap-Independent Viral Genome Translation | |
| 9:40 – 10:00 AM | Chen Gao; University of Cincinnati, USA Cardiac microexon regulation in cell death | |
| 10:00 – 10:20 AM | Wayne Miles; The Ohio State University, USA Coordinated Post-Transcriptional Regulation Facilitates PD-L1 Protein Production and Tumor Immune Suppression | |
| 10:20 AM | Break | |
| 10:40 AM | ||
| ISRNN Council Meeting | La Brea Room | |
| Personal Interaction, Communication, and Collaboration Among Attendees | Ballroom | |
| Visiting Company Exhibitions | ||
| 12:00 PM | Break for Lunch | |
| 1:00 PM | ||
| SESSION 6A: Extracellular Vesicles and Their Application in RNA Therapeutics (1) | Ballroom | |
| Session Moderator: Daniel Binzel & Randy Carney | ||
| 1:00 – 1:20 PM | Steven Jay; University of Maryland, USA Mechanical Regulation of Extracellular Vesicle Production and Cargo | |
| 1:20 – 1:40 PM | Cheemeng Tan; University of California Davis, USA High-Throughput and Cell-Free Engineering of Synthetic Extracellular Vesicles | |
| 1:40 – 2:00 PM | Eunji Chung; University of Southern California, USA Engineering Extracellular Vesicles as Nanotherapeutics for Cardiovascular and Chronic Diseases | |
| 2:00 – 2:20 PM | Emmanuele Cocucci; The Ohio State University, USA How Far Can an Extracellular Vesicle Journey from its Cell of Origin? | |
| SESSION 6B: Mechanisms of Biomotors for Packaging Double Stranded DNA | La Brea Room | |
| Session Moderator: Shujun Liu & Holland Cheng | ||
| 1:00 – 1:20 PM | Kiran Kondabagilu; Indian Institute of Technology Bombay, India Genome Packaging and Compaction in Mimivirus | |
| 1:20 – 1:40 PM | Robin Stanley; National Institutes of Health, USA Molecular Mechanisms of RNA Processing Machines | |
| 1:40 – 2:00 PM | Margaret Bohmer; The Ohio State University, USA — Selected Student Talk Constructing an Active Chimeric pRNA Ring with a Stoichiometry of Six and Identifying 12 Domains of the pRNA Ring Binding to the 12-Subunit Channel of Phi29 DNA Packaging Motor | |
| 2:00 – 2:20 PM | Tamar Schlick; New York University, USA Conformational Transitions of the SARS-CoV-2 Frameshifting element suggest translation mechanism | |
| 2:20 PM | Break | |
| 2:40 PM | ||
| SESSION 7A: Extracellular Vesicles and Their Application in RNA Therapeutics (2) | Ballroom | |
| Session Moderator: Steven Jay & Emmanuele Cocucci | ||
| 2:40 – 3:00 PM | Fei Liu; Harvard University, USA High-Throughput Production of Extracellular Vesicles for Diagnostic and Therapeutic Research | |
| 3:00 – 3:20 PM | Biao Lu; Santa Clara University, USA Genetic Engineering of Multifunctional Exosomes for Cancer Diagnosis and Therapy | |
| 3:20 – 3:40 PM | Dan Shu; The Ohio State University, USA Engineered Extracellular Vesicles for Combinatorial TNBC Therapy: SR-SIM-Guided Design Achieves Substantial Drug Dosage Reduction | |
| 3:40 – 4:00 PM | Xiaoning Bi; Western University, USA Extracellular Vesicle Dysregulation and Potential Therapeutic Application in Neurodevelopmental Disorders: Insights from Angelman Syndrome | |
| SESSION 7B: Oral Presentations from Abstracts and Posters | La Brea Room | |
| Session Moderator: Kai Jin & Margaret Bohmer | ||
| Oral presentations will be selected from the following abstracts and posters before the conference opens. | ||
| Muheebur Rehman; China Medical University, Taiwan A comparative study of cardiac enzymes (creatine kinase-myoglobin binding, troponin-i) and alkaline phosphatase in post myocardial infarction and healthy individuals Peshawar | ||
| Jayden Vega; El Dorado High School, USA FRET-Based Assay of Ikaros Ubiquitination by CRBN | ||
| Nehleen Reza; Ohio State University, USA Sterical configuration beyond conformation to RNA-protein interaction for executing functions in biological systems. | ||
| Qiaoya Zhang; Northwood High School, USA Fluorescent Reporter-Based Platform for Monitoring and Enhancing Tau and Aβ42 Degradation in Alzheimer’s Disease | ||
| Frank He; Walnut High School, USA A quantitative FRET-based assay for assessing the interaction between CRBN and c-Myc | ||
| Xueyun Gao; Beijing University of Technology, China A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF | ||
| Yiwei Tian; Zhaoliang Biotechnology Development (Shanghai) Co., Ltd, China Research proposal for the role and mechanism of 108CI/CT intravenous injection in myocardial ischemia and reperfusion injury | ||
| Jianing Li; Walnut High School, USA Investigating Corpus Collostomies and Alternative Treatments for Drug-Resistant Epilepsy in Pediatric and Adolescent Patients | ||
| Min Wu; University of Chinese Academy of Sciences, China Enhancing Immune Responses against Monkeypox: Chimeric Antigen Design and mRNA Vaccine Efficacy | ||
| 4:00 PM | Break | |
| 4:20 PM | Poster Session | |
| 6:30 PM | Break for Dinner and Social Time | |
WEDNESDAY, DECEMBER 17, 2025
| 9:00 AM | ||||
| SESSION 8A: Single Molecule Sensing and Counting in RNA Investigation | La Brea Room | |||
| Session Moderator: Xiaoning Bi & Guramrit Singh | ||||
| 9:00 – 9:20 AM | Soma Dhakal; Virginia Commonwealth University, USA High-Confidence Single-Molecule Detection of miRNAs | |||
| 9:20 – 9:40 AM | Jinbiao Ma; Fudan University, China Cryo-EM Structure of a Natural RNA Nanocage | |||
| 9:40 – 10:00 AM | Alex Johnson-Buck; University of Michigan, USA In Situ Multi-Omic Digital Biology via Single-Molecule Kinetic Fingerprinting | |||
| 10:00 – 10:20 AM | Steven Nguyen; Creighton University, USA — Selected Student Talk Optimization of a High-throughput FRET Assay to Study glmS Riboswitch Self-cleavage in Staphylococcus aureus | |||
| SESSION 8B: mRNA for Gene Therapy and Vaccines | Ballroom | |||
| Session Moderator: Guizhi (Julian) Zhu & Fei Liu | ||||
| 9:00 – 9:20 AM | Andrei Korostelev; University of Massachusetts, USA A Molecular Switch Between AUG and Non-AUG Translation | |||
| 9:20 – 9:40 AM | Shalini Oberfoerffer; National Cancer Institute, USA Exploring the Utility and Mechanisms of N4-Acetylcytidine in mRNA Therapeutics | |||
| 9:40 – 10:00 AM | Guramrit Singh; The Ohio State University, USA Connections Between mRNA Synthesis and Decay | |||
| 10:00 – 10:20 AM | Shujun Liu; Case Western Reserve University, USA Next Generation Oncology: Harnessing Precision mRNA Vaccines and Exosome Delivery | |||
| S | ||||
| 10:20 AM | Break | |||
| 10:40 AM | ||||
| SESSION 9A: RNA and EV Biology for Therapeutic Applications | Ballroom | |||
| Session Moderator: Jeffrey Kieft & Jinbiao Ma | ||||
| 10:40 – 11:00 AM | Jin Yu; University of California Irvine, USA Computational Interrogation on Mechanochemical and Fidelity Control of Human Mitochondrial RNA Polymerase and SARS-CoV-2 RNA Dependent RNA Polymerase in Comparison with Bacteriophage T7 RNA Polymerase | |||
| 11:00 – 11:20 AM | Randy Carney; University of California Davis, USA Nearing Single Vesicle-Resolved Lipidomics of Circulating Extracellular Vesicles (EVs) to Untangle the EV Interactome in Cancer | |||
| 11:20 – 11:40 AM | Julie Feigon; University of California Los Angeles, USA Structural Biology of Telomerase and Inhibition by Drugs | |||
| 11:40 – 12:00 PM | Dawn Chandler; The Ohio State University, USA Developing Cancer Models for Testing Splice Switching Therapies | |||
| SESSION 9B: Structure and Function of Biological Machines | La Brea Room | |||
| Session Moderator: Kiran Kondabagilu & Nikolay Dokholyan | ||||
| 10:40 – 11:00 AM | Xiangxi Wang; Chinese Academy of Sciences, China Viral Structures, Antibody Profiles and Vaccine Design | |||
| 11:00 – 11:20 AM | Holland Cheng; University of California Davis, USA Essence of Quaternary Structural Modularity in Novel Nanomedicine Designs | |||
| 11:20 – 11:40 AM | Wei Feng; Institute of Biophysics, CAS, China A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons | |||
| 11:40 – 12:00 PM | Tianmin Fu; University of Massachusetts, USA How Non-Coding RNA Controls the Activation of Retron Anti-phage Defense Systems | |||
| 12:00 PM | Break for Lunch | |||
| 1:30 PM | ||||
| SESSION 10A: Unique Roles and Applications of RNA with Therapeutic Potential | La Brea Room | |||
| Session Moderator: Andrei Korostelev & Gaurav Sahay | ||||
| 1:30 – 1:50 PM | Mohtadin Hashemi; Auburn University, USA Conformational Switching in APOBEC3G-RNA Complexes Revealed by High-Speed AFM and Molecular Simulations | |||
| 1:50 – 2:10 PM | Guizhi (Julian) Zhu; University of Michigan, USA Engineering and delivery of circRNA therapeutics and vaccines | |||
| 2:10 – 2:30 PM | Fan Hong; University of Florida, USA Programmable RNA molecular devices for biosensing and cellular regulation | |||
| 2:30 – 2:50 PM | Ana Luisa Duran Meza; University of California Los Angeles, USA Plant-Derived Virus-Like Particles as Versatile Nanocarriers for Therapeutic RNA Delivery in Mammalian Systems | |||
| SESSION 10B: Nanodevices and Their Application in RNA Studies | Ballroom | |||
| Session Moderator: Dawn Chandler & Rajgopal Govindarajan | ||||
| 1:30 – 1:50 PM | Li-Chun Tu; The Ohio State University, USA A Programmable sgRNA Tool for Engineering Chromatin Architecture in Live Cells | |||
| 1:50 – 2:10 PM | Gaurav Sahay; Oregon State University, USA Strategies for Non-Viral Vectors Targeting Organs Beyond the Liver | |||
| 2:10 – 2:30 PM | Nikolay Dokholyan; University of Virginia, USA Spread of Motor Neuron Death in ALS | |||
| 2:30 – 2:50 PM | Mingxu You; University of Massachusetts, USA Multiplexed RNA Imaging and Live-Cell Profiling Using Genetically Encodable Fluorogenic | |||
| 2:50 PM | Peixuan Guo; The Ohio State University, USA Closing Remarks and Awards | Ballroom | ||

