Conference of RNA, Exosome and Nanomedicine

5th International Conference on Biomotors, Virus Assembly, and RNA Nanobiotechnology

Hosted by:   International Society of RNA Nanotechnology & Nanomedicine (ISRNN) ,   The International Association of Biomedical Sciences (IABS)
Co-sponsered by:   Center for RNA Nanobiotechnology and Nanomedicine AND Center for RNA Biology , The Ohio State University

Registration Fees
PI / Scientist / Clinician$ 590
Postdoc / PhD / Graduate /Undergraduate$ 390
High schoolers$ 200
Oline$ 230
Note: Including three days lunch.

We are pleased to announce the Conference of RNA, Exosome and Nanomedicine. This is the 5th installment of the biennial International Conference on Biomotors, Virus Assembly, and RNA Nanobiotechnology series since 2017. Due to the RNA field arriving as the third milestone in pharmaceutical drug development, we extended the previous conference series to focus on RNA for this conference. Since exosomes contain many RNAs inside and RNA can display on the surface of exosomes for the purpose of RNA delivery, exosome is another focus of this conference. This interdisciplinary conference includes leading scientists and engineers working in the diverse fields of chemistry, biochemistry, biophysics, structural biology, microbiology, cell biology, materials, and nanotechnology to participate. We invite you to join us in this exciting conference featuring interdisciplinary talks from many fields of groundbreaking research.
To ensure the promotion of high quality and effective academic communication, the conference will be limited to 300 attendees and 50 invited speakers that will be selected from the current more than 200 candidates recommended by members of the Scientific Committee. Registration will be accepted first come first-served basis till the 300 slots are filled. All members of the ISRNN (International Society of RNA Nanotechnology and Nanomedicine https://www.myisrnn.org/ ) and IABS (International Association of Biomedical Sciences https://ia-bs.org/ ) will provide a $100-discount on registration fee and a waiver for the publication fee on journal RNA NanoMed for the year of 2025 (see journal web site https://rnananomed.org/ and its papers indexed by Pubmed https://pubmed.ncbi.nlm.nih.gov/?term=%22RNA+NanoMEd%22%5BJournal%5D&sort ).

Conference Chair

Peixuan Guo

Fellow of National Academy of Inventors,
Editor in Chief of RNA NanoMed,
Sylvan Frank Endowed Chair,
College of Pharmacy,
College of Medicine,
Director, Center for
RNA Nanobiotech & Nanomed,
President, Intl. Society of
RNA Nanotech & Nanomed (ISRNN),
The Ohio State University

Co-chair

Kirill Afonin

Professor;
Dept. of Chemistry;
University of North Carolina
– Charlotte, USA

Karin Musier-Forsyth

Professor;
Dept. of Chemistry
and Biochemistry;
The Ohio State University,
Columbus, USA

Sarah Woodson

T.C. Jenkins Professor;
Dept. of Biophysics;
Johns Hopkins University,      
Baltimore, USA

Eric WESTHOF

Professeur(e) Emérite
Institut de biologie;
Université de Strasbourg,      
Strasbourg, France

Organizers and Scientific Program Committees:

Sarah Woodson

Scientific Committee Chair;

Professor; Johns Hopkins University, USA

Kirill Afonin

Scientific Committee Member;

Professor; University of North Carolina – Charlotte, USA

Peixuan Guo

Scientific Committee Member;

Professor & Director of Center for RNA Nanobiotechnology and Nanomedicine;
The Ohio State University, USA

Daniel Binzel

Scientific Committee Member;

Research Assistant Professor;
The Ohio State University, USA

Karin Musier-Forsyth

Scientific Committee Member;

Professor; The Ohio State University, USA

Aijun Wang

Scientific Committee Member;

Professor; University of California, Davis, USA

Eric Westhof

Scientific Committee Member;

Professeur(e) Emérite;
Université de Strasbourg, France

Speakers and Session Chairs (listed in first name alphabetical order)

Abstract Submission

Please download the abstract template for your abstract preparation. ( Click Here )

Poster Submission

Poster size: 40″ Wx 30″ H. Email your PDF file to conference@ia-bs.org before December 1, 2025. Save your file as “your Name-2025 Poster”.

If you need printing by the conference organizer. A fee of $90 will apply for this service.” ( Click Here )

.

Hotel Information

DoubleTree by Hilton Los Angeles – Rosemead
Address: 888 Montebello Blvd, Rosemead, CA 91770
Phone: +1 323-722-8800

Book Your Room:
www.LosAngelesRosemead.DoubleTree.com
After booking your hotel using the link above, please provide us with your names by emailing conference@ia-bs.org.
We can request the hotel to reimburse the difference so your rate matches the conference discount rate of $155 before tax, which includes free breakfast and free parking.

Airports

Ontario International Airport (ONT)
2500 E. Airport Drive
Ontario, CA 91761, USA
Website: https://www.flyontario.com/

Los Angeles International Airport (LAX)
1 World Way
Los Angeles, CA 90045, USA
Website: https://www.flylax.com/

Acknowledgment of Financial Sponsors:

1. National Institutes of Health, National Center for Advancing Translational Sciences

Scientific Sponsors:

1. The Ohio State University

2. Center for RNA Nanobiotechnology and Nanomedicine, OSU

3. Center for RNA Biology, OSU

4. College of Pharmacy, OSU

5. International Society of RNA Nanotechnology and Nanomedicine

6. International Association of Biomedical Sciences

.

TENTATIVE AGENDA

Scientific Program December 15 – 17, 2025

MONDAY, DECEMBER 15, 2025

9:00 AMBallroom
9:00 – 9:30 AMPeixuan Guo; The Ohio State University, USA Introduction: The Current Advancement of RNA Nanotechnology, Extracellular Vesicles, and RNA-displaying EVs
 
9:30 AM 
SESSION 1: RNA, Virus Assembly, and ExosomesBallroom
Session Moderator: Peixuan Guo & Thomas Webster
9:30 – 10:00 AMKarin Musier-Forsyth; The Ohio State University, USA How Structure Determines HIV-1 Unspliced RNA Fate: A Tale of Two Gs
10:00 – 10:30 AMZihe Rao; Tsinghua University, China Cryo-EM Structural Imaging of the Revolving Hexameric DNA Packaging Motor of Human Herpesvirus
  
10:30 – 11:00 AMMeeting Logistics and Break
  
11:00 – 11:30 AMAijun Wang; University of California Davis, USA Engineering Extracellular Vesicles and Lipid Nanoparticles for Targeted Delivery and Therapy
11:30 – 12:00 PMGene Yeo; University of California San Diego, USA Discovery of Circular RNA Biogenesis Regulators 
 
12:00 PMBreak for Lunch
 
1:30 PM 
SESSION 2: RNA Structure, Aggregation, and NanotechnologyBallroom
Session Moderator: Jane Jackman & Julie Feigon
1:30 – 2:00 PMJeffrey Kieft; New York Structural Biology Center and Columbia University, USA Viral RNA Structures that Manipulate Cellular Machinery
2:00 – 2:30 PMKirill Afonin; University of North Carolina Charlotte, USA Nucleic Acid Nanoparticles for Biomedical Applications
2:30 – 3:00 PMSarah Woodson; Johns Hopkins University, USA Mechanisms of RNA Aggregation in Triplet Repeat Expansion Disease
 
3:00 PMBreak
 
3:30 PM 
SESSION 3A: RNA with Unique Functionality: Small Noncoding RNA and Long Noncoding RNA (1)La Brea Room
Session Moderator: Yibin Feng & Soma Dhakal
3:30 – 3:50 PMRajgopal Govindarajan; The Ohio State University, USA Cardioprotective SNPs in SLC28A3 and lncRNA SLC28A3-AS1 Result in Transcriptional Changes and Alternative Splicing to Reduce Doxorubicin Cytotoxicity
3:50 – 4:10 PMWenqiang Yu; Fudan University, China NamiRNA-Enhancer Network as Novel Target for Developing Small Nuclear Acid Therapy
4:10 – 4:30 PMTae Jin Lee; University of Texas Health Science Center at Houston, USA Targeting microRNAs for Treating Glioblastoma with Engineered Extracellular Vesicles
4:30 – 4:50 PMYibin Feng; The University of Hong Kong, Hong Kong Multidisciplinary research and drug discovery in Chinese medicine: coptis and berberine as the case
 
SESSION 3B: RNA Processing and RegulationBallroom
Session Moderator: Karin Musier-Forsyth & Gene Yeo
3:30 – 3:50 PMAmbro van Hoof; The Ohio State University, USA tRNA Splicing Endonuclease is a Multifunctional Enzyme with Roles in Maturation and Degradation of Diverse RNA
3:50 – 4:10 PMKay Choi; Indiana University, USA Lessons from the Structure of the HIV Rev Response Element
4:10 – 4:30 PMKristin Koutmou; University of Michigan, USA The Molecular Level Consequences of RNA Modifications on Protein Synthesis
4:30 – 4:50 PMShipra Agrawal; Stony Brook University, USA Alternative RNA Splicing and Polyadenylation in Chronic Kidney Disease
 
4:50 PMBreak
 
5:10 PM 
SESSION 4A: RNA with Unique Functionality: Small Noncoding RNA and Long Noncoding RNA (2)La Brea Room
Session Moderator: Kirill Afonin & Elisa Franco
5:10 – 5:30 PMWen Zhang; Indiana University, USA Mirror-image Nucleic Acids as Next-generation Reagents for Basic Research and Therapeutic Applications
5:30 – 5:50 PMDaniel Binzel; The Ohio State University, USA RNA Nanoparticles Harboring Radioisotopes or Other Imaging Molecules for Spontaneous Tumor Targeting for Early Cancer Diagnosis
5:50 – 6:10 PMKai Jin; The Ohio State University, USA — Selected Student Talk Illustration of the Variable 1D Sequences and Conserved 2D and 3D Structures of Different ncRNA Nanostructures for Tracking the Evolution and Origin of Organisms
6:10 – 6:30 PMLalit Sehgal; The Ohio State University, USA MALAT1 Long-Non-Coding RNA Regulates SOX11 Expression in Mantle Cell Lymphoma
 
SESSION 4B: Advances in RNA Therapeutics and RNA Delivery VehiclesBallroom
Session Moderator: Aijun Wang & Eunji Chung
5:10 – 5:30 PMThomas Webster; Brown University, USA Human Nanomedicine: Using the G^C DNA Motif to Grow Tissue, Fight Infection, and Inhibit Inflammation
5:30 – 5:50 PMMinsun Song; City of Hope, USA Transferrin Receptor-Targeted RNA Aptamer Enhances Blood-Brain Barrier Penetration in Brain Metastases from Triple-Negative Breast Cancer
5:50 – 6:10 PMMarina Dobrovolskaia; Nanotechnology Characterization Laboratory, USA Translational Journey of Nanomedicines: General and RNA- Nanotechnology-specific Challenges, Solutions and Perspective from the Nanotechnology Characterization Laboratory Assay Cascade Experiences
6:10 – 6:30 PMElisa Franco; University of California Los Angeles, USA Programmable Artificial RNA Condensates in Mammalian Cells
 
6:40 PMBreak for Dinner
 
8:00 PMSocial Hour

TUESDAY, DECEMBER 16, 2025

9:00 AM 
SESSION 5A: RNA Structure and Function to Build Biological MachinesBallroom
Session Moderator: Sarah Woodson & Deepak Koirala
9:00 – 9:20 AMJane Jackman; The Ohio State University, USA Harnessing the Unusual Chemistry and Biology of tRNA Modification Enzymes
9:20 – 9:40 AMLela Lackey; Clemson University, USA Sequence and structural characteristics of conserved splice junctions surrounding neural microexons
9:40 – 10:00 AMYin Chen; University of Arizona, USA MARCKS-driven nano-defenders (MDND) as a prototype for novel anti-infectious therapy
10:00 – 10:20 AMYun-xing Wang; National Cancer Institute, USA RNA Conformational Space Beyond Static Structure
 
SESSION 5B: Cellular Function Regulated by RNALa Brea Room
Session Moderator: Wayne Miles & Alex Johnson-Buck
9:00 – 9:20 AMJaimie Stewart; University of California Los Angeles, USA Building and Tuning Synthetic RNA Condensates: Experimental Design Principles and Computational Insights
9:20 – 9:40 AMDeepak Koirala; University of Maryland Baltimore, USA RNA Structure-Based Strategies of Cap-Independent Viral Genome Translation
9:40 – 10:00 AMChen Gao; University of Cincinnati, USA Cardiac microexon regulation in cell death
10:00 – 10:20 AMWayne Miles; The Ohio State University, USA Coordinated Post-Transcriptional Regulation Facilitates PD-L1 Protein Production and Tumor Immune Suppression
  
10:20 AMBreak
  
10:40 AM 
ISRNN Council MeetingLa Brea Room
 
Personal Interaction, Communication, and Collaboration Among AttendeesBallroom
 
Visiting Company Exhibitions
 
12:00 PMBreak for Lunch
 
1:00 PM 
SESSION 6A: Extracellular Vesicles and Their Application in RNA Therapeutics (1)Ballroom
Session Moderator: Daniel Binzel & Randy Carney
1:00 – 1:20 PMSteven Jay; University of Maryland, USA Mechanical Regulation of Extracellular Vesicle Production and Cargo
1:20 – 1:40 PMCheemeng Tan; University of California Davis, USA High-Throughput and Cell-Free Engineering of Synthetic Extracellular Vesicles
1:40 – 2:00 PMEunji Chung; University of Southern California, USA Engineering Extracellular Vesicles as Nanotherapeutics for Cardiovascular and Chronic Diseases
2:00 – 2:20 PMEmmanuele Cocucci; The Ohio State University, USA How Far Can an Extracellular Vesicle Journey from its Cell of Origin?
 
SESSION 6B: Mechanisms of Biomotors for Packaging Double Stranded DNALa Brea Room
Session Moderator: Shujun Liu & Holland Cheng
1:00 – 1:20 PMKiran Kondabagilu; Indian Institute of Technology Bombay, India Genome Packaging and Compaction in Mimivirus
1:20 – 1:40 PMRobin Stanley; National Institutes of Health, USA Molecular Mechanisms of RNA Processing Machines
1:40 – 2:00 PMMargaret Bohmer; The Ohio State University, USA — Selected Student Talk Constructing an Active Chimeric pRNA Ring with a Stoichiometry of Six and Identifying 12 Domains of the pRNA Ring Binding to the 12-Subunit Channel of Phi29 DNA Packaging Motor
2:00 – 2:20 PMTamar Schlick; New York University, USA Conformational Transitions of the SARS-CoV-2 Frameshifting element suggest translation mechanism
 
2:20 PMBreak
 
2:40 PM 
SESSION 7A: Extracellular Vesicles and Their Application in RNA Therapeutics (2)Ballroom
Session Moderator: Steven Jay & Emmanuele Cocucci
2:40 – 3:00 PMFei Liu; Harvard University, USA High-Throughput Production of Extracellular Vesicles for Diagnostic and Therapeutic Research
3:00 – 3:20 PMBiao Lu; Santa Clara University, USA Genetic Engineering of Multifunctional Exosomes for Cancer Diagnosis and Therapy
3:20 – 3:40 PMDan Shu; The Ohio State University, USA Engineered Extracellular Vesicles for Combinatorial TNBC Therapy: SR-SIM-Guided Design Achieves Substantial Drug Dosage Reduction
3:40 – 4:00 PMXiaoning Bi; Western University, USA Extracellular Vesicle Dysregulation and Potential Therapeutic Application in Neurodevelopmental Disorders: Insights from Angelman Syndrome
 
SESSION 7B: Oral Presentations from Abstracts and PostersLa Brea Room
Session Moderator: Kai Jin & Margaret Bohmer
Oral presentations will be selected from the following abstracts and posters before the conference opens.
 Muheebur Rehman; China Medical University, Taiwan  A comparative study of cardiac enzymes (creatine kinase-myoglobin binding, troponin-i) and alkaline phosphatase in post myocardial infarction and healthy individuals Peshawar
 Jayden Vega; El Dorado High School, USA FRET-Based Assay of Ikaros Ubiquitination by CRBN
 Nehleen Reza; Ohio State University, USA Sterical configuration beyond conformation to RNA-protein interaction for executing functions in biological systems.
 Qiaoya Zhang; Northwood High School, USA Fluorescent Reporter-Based Platform for Monitoring and Enhancing Tau and Aβ42 Degradation in Alzheimer’s Disease
 Frank He; Walnut High School, USA A quantitative FRET-based assay for assessing the interaction between CRBN and c-Myc
 Xueyun Gao; Beijing University of Technology, China A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
 Yiwei Tian; Zhaoliang Biotechnology Development (Shanghai) Co., Ltd, China Research proposal for the role and mechanism of 108CI/CT intravenous injection in myocardial ischemia and reperfusion injury
 Jianing Li; Walnut High School, USA Investigating Corpus Collostomies and Alternative Treatments for Drug-Resistant Epilepsy in Pediatric and Adolescent Patients
 Min Wu; University of Chinese Academy of Sciences, China Enhancing Immune Responses against Monkeypox: Chimeric Antigen Design and mRNA Vaccine Efficacy
 
4:00 PMBreak
 
4:20 PMPoster Session
 
6:30 PMBreak for Dinner and Social Time

WEDNESDAY, DECEMBER 17, 2025

9:00 AM 
SESSION 8A: Single Molecule Sensing and Counting in RNA InvestigationLa Brea Room
Session Moderator: Xiaoning Bi & Guramrit Singh
9:00 – 9:20 AMSoma Dhakal; Virginia Commonwealth University, USA High-Confidence Single-Molecule Detection of miRNAs
9:20 – 9:40 AMJinbiao Ma; Fudan University, China Cryo-EM Structure of a Natural RNA Nanocage
9:40 – 10:00 AMAlex Johnson-Buck; University of Michigan, USA In Situ Multi-Omic Digital Biology via Single-Molecule Kinetic Fingerprinting
10:00 – 10:20 AMSteven Nguyen; Creighton University, USA — Selected Student Talk Optimization of a High-throughput FRET Assay to Study glmS Riboswitch Self-cleavage in Staphylococcus aureus
 
SESSION 8B: mRNA for Gene Therapy and VaccinesBallroom
Session Moderator: Guizhi (Julian) Zhu & Fei Liu
9:00 – 9:20 AMAndrei Korostelev; University of Massachusetts, USA A Molecular Switch Between AUG and Non-AUG Translation
9:20 – 9:40 AMShalini Oberfoerffer; National Cancer Institute, USA Exploring the Utility and Mechanisms of N4-Acetylcytidine in mRNA Therapeutics
9:40 – 10:00 AMGuramrit Singh; The Ohio State University, USA Connections Between mRNA Synthesis and Decay
10:00 – 10:20 AMShujun Liu; Case Western Reserve University, USA Next Generation Oncology: Harnessing Precision mRNA Vaccines and Exosome Delivery
S
10:20 AM Break
 
10:40 AM 
SESSION 9A: RNA and EV Biology for Therapeutic ApplicationsBallroom
Session Moderator: Jeffrey Kieft & Jinbiao Ma
10:40 – 11:00 AMJin Yu; University of California Irvine, USA Computational Interrogation on Mechanochemical and Fidelity Control of Human Mitochondrial RNA Polymerase and SARS-CoV-2 RNA Dependent RNA Polymerase in Comparison with Bacteriophage T7 RNA Polymerase
11:00 – 11:20 AMRandy Carney; University of California Davis, USA Nearing Single Vesicle-Resolved Lipidomics of Circulating Extracellular Vesicles (EVs) to Untangle the EV Interactome in Cancer
11:20 – 11:40 AMJulie Feigon; University of California Los Angeles, USA Structural Biology of Telomerase and Inhibition by Drugs
11:40 – 12:00 PMDawn Chandler; The Ohio State University, USA Developing Cancer Models for Testing Splice Switching Therapies
 
SESSION 9B: Structure and Function of Biological MachinesLa Brea Room
Session Moderator: Kiran Kondabagilu & Nikolay Dokholyan
10:40 – 11:00 AMXiangxi Wang; Chinese Academy of Sciences, China Viral Structures, Antibody Profiles and Vaccine Design
11:00 – 11:20 AMHolland Cheng; University of California Davis, USA Essence of Quaternary Structural Modularity in Novel Nanomedicine Designs
11:20 – 11:40 AMWei Feng; Institute of Biophysics, CAS, China A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons
11:40 – 12:00 PMTianmin Fu; University of Massachusetts, USA How Non-Coding RNA Controls the Activation of Retron Anti-phage Defense Systems
 
12:00 PM Break for Lunch
 
1:30 PM 
SESSION 10A: Unique Roles and Applications of RNA with Therapeutic Potential La Brea Room
Session Moderator: Andrei Korostelev & Gaurav Sahay
1:30 – 1:50 PMMohtadin Hashemi; Auburn University, USA Conformational Switching in APOBEC3G-RNA Complexes Revealed by High-Speed AFM and Molecular Simulations
1:50 – 2:10 PMGuizhi (Julian) Zhu; University of Michigan, USA Engineering and delivery of circRNA therapeutics and vaccines
2:10 – 2:30 PMFan Hong; University of Florida, USA Programmable RNA molecular devices for biosensing and cellular regulation
2:30 – 2:50 PMAna Luisa Duran Meza; University of California Los Angeles, USA Plant-Derived Virus-Like Particles as Versatile Nanocarriers for Therapeutic RNA Delivery in Mammalian Systems
 
SESSION 10B: Nanodevices and Their Application in RNA StudiesBallroom
Session Moderator: Dawn Chandler & Rajgopal Govindarajan
1:30 – 1:50 PMLi-Chun Tu; The Ohio State University, USA A Programmable sgRNA Tool for Engineering Chromatin Architecture in Live Cells
1:50 – 2:10 PMGaurav Sahay; Oregon State University, USA Strategies for Non-Viral Vectors Targeting Organs Beyond the Liver
2:10 – 2:30 PMNikolay Dokholyan; University of Virginia, USA Spread of Motor Neuron Death in ALS
2:30 – 2:50 PMMingxu You; University of Massachusetts, USA Multiplexed RNA Imaging and Live-Cell Profiling Using Genetically Encodable Fluorogenic
 
2:50 PMPeixuan Guo; The Ohio State University, USA Closing Remarks and AwardsBallroom

Registration Deadline Expired!!

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