Dr. Christine E. Brown is the Heritage Provider Network Professor in Immunotherapy and Professor in the Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology at City of Hope. She is also the Deputy Director of the T Cell Therapeutics Research Laboratories (TCTRL), where she leads multi-functional teams to translate CAR T cell therapies to the clinic. Dr. Brown’s research laboratory aims to develop, optimize, and translate CAR T cell approaches for the treatment of malignant brain tumors. Her efforts to develop glioblastoma-targeted CAR T cells, improve T cell manufacturing, and optimize routes of T cell delivery have led to the initiation of several first-in-human clinical trials. In this presentation she will discuss insights from these ongoing clinical trials and next-generation approaches to address challenges limiting the effectiveness of CAR T cell therapy.
City of Hope, USA